Complications of hydatidiform mole

Other medical complications included those related to increased beta-hCG titers such as preeclampsia, hyperthyroidism and pulmonary insufficiency. The most common histopathologic diagnosis (71%) was complete hydatidiform mole. Seventy percent of patients were given methotrexate chemoprophylaxis, mainly due to serum hCG > 100,000 mIU/ mL A molar pregnancy — also known as hydatidiform mole — is a rare complication of pregnancy characterized by the abnormal growth of trophoblasts, the cells that normally develop into the placenta. There are two types of molar pregnancy, complete molar pregnancy and partial molar pregnancy

Honorary Assistant Gynaecologist. King George V Memorial Hospital, Royal Prince Alfred Hospital, Sydney, Australia. Search for more papers by this autho Hydatidiform moles can cause serious complications, including the following: Infection of the uterus A widespread infection of the blood (sepsis) Dangerously low blood pressure (shock

Hydatidiform mole and its complications: review of patient

  1. HM, or molar pregnancy, results from abnormal fertilization of the oocyte (egg). It results in an abnormal fetus. The placenta grows normally with little or no growth of the fetal tissue. The placental tissue forms a mass in the uterus
  2. When the proliferation/invasion phenomena are not well controlled, the trophoblast cells can give rise to a rare complication of pregnancy known as a hydatidiform mole (complete or partial). These hydatidiform moles belong to the gestational trophoblastic diseases of which represent the most common pathologies
  3. GTD with thyrotoxicosis is a rare clinical scenario, but thyroid hyperstimulation by hCG can have severe clinical consequences. Complete hydatidiform mole most commonly presents with vaginal bleeding, occurring at 6 to 16 weeks of gestation in 80% to 90% of cases (1)
  4. Hydatidiform mole is one of these conditions wherein trophoblasts abnormally grow in the womb. Instead of maturing into a normal pregnancy, this hydatidiform moles, or molar pregnancies, resemble fluid-filled cysts (called moles) that occupy the womb

Hydatidiform moles are a common complication of pregnancy, occurring once in every 1000 pregnancies in the US, with much higher rates in Asia (e.g. up to one in 100 pregnancies in Indonesia). When inspected in the microscope, hyperplasia of the trophoblastic tissue is noted Diagnosis and management of hydatidiform mole and its complications: 2000 years of a medical challenge. Jauniaux E(1), Verheijen R(2). Author information: (1)Academic Department of Obstetrics and Gynaecology, Institute for Women's Health, University College London, London, UK Complications Of Molar Pregnancy. A molar pregnancy or a hydatidiform mole is a chance complication of pregnancy. It occurs due to an abnormal and awry growth of the cells that were to grow and become placenta. The cells are known as trophoblasts. A hydatidiform mole cannot be sustained as a normal pregnancy and needs to be removed with.

Hydatidiform mole is an abnormal pregnancy characterized by varying degrees of trophoblastic proliferation (both cytotrophoblast and syncytiotrophoblast) and vesicular swelling of placental villi associated with an absent or abnormal fetus/embryo Medical Complications of Hydatidiform Mole Common complications include anemia, infection, hyperthyroidism, pregnancy-induced hypertension or pre-eclampsia, and theca lutein cysts. Anemia : A hemoglobin of less than 10 g/dL, seen in 50% of patients with complete moles and results from excessive vaginal bleeding Pre-eclampsia: occurs in. A molar pregnancy also known as hydatidiform mole, is an uncommon complication of pregnancy where a fetus doesn't form properly in the womb and a baby doesn't develop. A lump of abnormal cells grows in the womb instead of a healthy fetus. There are two types of molar pregnancies, complete and partial

Molar pregnancy - Symptoms and causes - Mayo Clini

  1. Hydatidiform mole (HM) is a rare mass or growth that forms inside the womb (uterus) at the beginning of a pregnancy. It is a type of gestational trophoblastic disease (GTD). The uterus is a hollow muscular organ located in the female pelvis between the bladder and rectum. The ovaries produce the eggs that travel through the fallopian tubes
  2. Molar Pregnancy: Symptoms, Risks, and Treatment. A molar pregnancy is an abnormality of the placenta, caused by a problem when the egg and sperm join together at fertilization. Also called gestational trophoblastic disease (GTD), hydatidiform mole or simply referred to as a mole, this is a rare condition occurring in 1 out of every 1,000 pregnancies
  3. Hydatidiform mole is a disease of pregnancy and therefore a disease of women. Hydatidiform mole is more common at the extremes of reproductive age. Women in their early teenage or perimenopausal years are most at risk. [ 1, 14, 16, 18, 19] Women older than 35 years have a 2-fold increase in risk
  4. A hydatidiform mole is a growing mass of tissue inside the womb (uterus) that will not develop into a baby. It is the result of abnormal conception. A hydatidiform mole may be either complete or partial. Sometimes, during conception, a sperm fertilises an 'empty' egg (ovum). This is an ovum not carrying any chromosomes or genetic material
  5. g an invasive mole. Incomplete moles can become invasive (<5% risk) but are not associated with choriocarcinoma
  6. Most (> 80%) hydatidiform moles are benign. The rest may persist, tending to become invasive; 2 to 3% of hydatidiform moles are followed by choriocarcinoma. Overall incidence of gestational trophoblastic neoplasia is about 1/40,000 pregnancies (1, 2)

Abstract:Hydatidiform mole cases are usually uncomplicated. However, few cases can be associated with perioperative complications of a critical nature, which can lead to substantial mortality and morbidity. Here is a report of one such case, which, in spite of extensive perioperative management, led to mortality There are several causes of respiratory failure in patients with hydatidiform mole, including pulmonary edema, pleural effusion, pulmonary embolism, and trophoblastic embolization. 16, 35 The radiographic features of pulmonary edema, pleural effusion, and pulmonary embolism in patients with molar pregnancies do not differ from those in patients without this condition Uterine enlargement beyond the expected gestational age, theca lutein cysts, and medical complications of molar pregnancy such as pregnancy-induced hypertension, hyperthyroidism, anemia, respiratory distress, and hyperemesis more frequently affect patients with complete moles diagnosed later in pregnancy. 3 Postmolar gestational trophoblastic neoplasia is diagnosed more frequently after complete than partial moles (Table 1). It is also called a hydatidiform mole. Molar pregnancies are a type of gestational trophoblastic disease. In a molar pregnancy, a tumor grows in the uterus. The tumor forms as fluid-filled cysts resembling clusters of grapes. Who is likely to have a molar pregnancy? What complications are associated with molar pregnancy Objective. To evaluate the ultrasound diagnostic rates of complete hydatidiform moles (CHM) and partial hydatidiform moles (PHM) in women presenting with a missed miscarriage, the clinical complications at diagnosis and the risk of gestational trophoblastic neoplasia (GTN) after surgical evacuation and to compare our findings with those of the published literature by completing a systematic.

Gestational trophoblastic disease (GTD) is a rare complication of pregnancy that may be associated with thyrotoxicosis. The incidence of hydatidiform mole in the United States and other developed countries is about 1 in 1500 live births (1). Complete moles have the highest incidence of thyrotoxicosis, predominantly affect younger women, and present with vaginal bleeding most of the time Molar Pregnancy - H Mole Or Hydatidiform Mole. A molar pregnancy occurs when the placenta develops into an abnormal mass of cysts rather than becoming a viable pregnancy. Molar pregnancy is a type of gestational trophoblastic disease (GTD). In a complete molar pregnancy, there's no embryo or normal placental tissue The incidence of hydatidiform mole varies between ethnic groups, and typically occurs in 1 in every 1500 pregnancies. All hydatidiform mole cases are sporadic, except for extremely rare familial cases. A maternal gene has been identified for recurrent hydatidiform mole (chromosome 19q13.3-13.4 in a 15.2 cM interval flanked by D19S924 and D19S890) Hydatidiform (Vesicular) Mole. It is a benign neoplasm of the chorionic villi. Incidence. 1:2000 pregnancies in United States and Europe, but 10 times more in Asia. The incidence is higher toward the beginning and more toward the end of the childbearing period. It is 10 times more in women over 45 years old. Pathology

A partial hydatidiform mole is a completely independent ailment to complete hydatidiform mole. Partial hydatidiform mole presents to the physician as a mixture of normal villous placental trophoblastic tissue, hygromatous balls or cysts, and some fetal fragments, without an intact fetus A molar pregnancy is also called a mole, a hydatidiform mole, or gestational trophoblastic disease. You can have this pregnancy complication even if you have had a typical pregnancy before

A complete mole occurs when an empty ovum is fertilized by a sperm. About 80% of complete hydatidiform moles are 46XX, which originate from duplication of the chromosomes of a haploid sperm; the other 20% are 46XY; all the chromosomes are paternally derived. Although all chromosomes are paternally derived, mitochondrial DNA remains maternal in. Maybe able to save the baby. Need to be examined for hydatidiform mole or ectopic pregnancy. -Imminent AB: placenta has separated, cervix dilated, amount of bleeding has increased -Complete abortion: All the products of conception are expelled. The uterus is contracted and the cervical os may be closed

A hydatidiform mole with a coexisting fetus is a rare condition that commonly occurs as either a partial mole with fetus or a twin pregnancy comprising a complete mole and normal fetus. In the former case, the fetus is triploid, and in the latter case, the fetus is diploid with different alleles from those of the mole. Because there is a difference in the persistent trophoblastic disease. Sex: Hydatidiform mole is a disease of pregnancy, and therefore a disease of women. Age: Hydatidiform mole is more common at the extremes of reproductive age. The early teens and the perimenopause years are most at risk. Women over age 35 have a twofold increase in risk Invasive mole and choriocarcinoma are suspected if biopsy findings suggest invasive disease or if beta-hCG levels remain higher than expected after treatment for hydatidiform mole (see below). Thyroid function tests are done if the beta-hCG level is > 100,000 mIU/mL (> 100,000 IU/L) to check for hyperthyroidism Hydatidiform mole (molar pregnancy) is the pre-malignant form of gestational trophoblastic neoplasia. It is of clinical and epidemiological interest because of its significant complication in. Start studying Chapter 28-Complications of Pregnancy-Hydatidiform Mole(Molar Pregnancy), Ectopic Pregnancy, Spontaneous Abortion, Incompetent Cervix. Learn vocabulary, terms, and more with flashcards, games, and other study tools

Most of these tumors occur after a full-term pregnancy, but they may arise after a spontaneous abortion or evacuation of hydatidiform mole. Vaginal bleeding is the presenting symptom in two-thirds of patients; about one third of patients present with metastatic disease. Serum beta human chorionic gonadotropin (hCG) levels are mildly elevated The demographics, clinical course, management options and complications, monitoring and progression to malignancy, and histopathologic diagnosis of these patients were reviewed. Results From January 2008-December 2012 there were 551 cases of molar pregnancies. The hospital-based incidence of hydatidiform mole was 13.38/1,000 pregnancies Centre (NETDC) mentioned that 20% of hydatidiform mole cases have thyrotoxicosis as one of its complications. The basic pathogenesis of thyrotoxicosis is the similarity of the HCG subunit to TSH which results in excessive stimulation of thyroid hormone. We present thethyrotoxicosis case in a 15-weeks pregnant woman with complete hydatidiform mole Hydatidiform mole (H. mole), or Kyawa in vernacular, is a disease caused by an abnormal proliferation of trophoblastic villi which leads to a grape-like mass in the uterus. It is the benign kind of Gestational Trophoblastic Disease (GTD) while the cancerous kind is Invasive mole, Epithelioid trophoblastic tumor, Choriocarcinoma and Placental.


  1. al pai
  2. e the incidence, epidemiology, complications and management of Hydatidiform mole (HM) at the King Fahd Hospital of the.
  3. Hydatidiform mole (HM) is one of a group of diseases that develop from abnormal proliferation of trophoblast and are classified as gestational trophoblastic disease (GTD). The two distinct types of HM, complete mole and partial mole, have different karyotypes, gross and microscopic histopathology, clinical presentations, and prognoses [ 1-3 ]
  4. With the increased availability of sensitive hCG assays and increased use of routine early ultrasound evaluations in pregnancy leading to more frequent diagnosis in early pregnancy, the classical features of hydatidiform moles are observed less often than previously. 10-13 Medical complications occur in approximately 25% of patients with.
  5. Hydatidiform mole, in human pregnancy, abnormal growth of the chorion, the outermost vascular membrane that in a normal pregnancy would enclose the embryo and ultimately give rise to the placenta.In the situation in which the hydatidiform mole develops, the embryo is usually either absent or dead. The mole, a collection of sacs (cysts) containing a jellylike substance, resembles clusters of.

hemorrhagic complication in first trimester

Small mole-D&C (have to empty the uterus). Will do chest xrays to determine metastasis. Will measure hCGs weekly until normal ; rechecked q2-4 weeks; then every 1-2 months for 6 months to a year Overview. Hydatidiform mole (or mola hydatidiforma) is a common complication of pregnancy, it consists of a nonviable embryo which implants and proliferates within the uterus. The term is derived from hydatidiform (like a bunch of grapes) and mole (from Latin mola = millstone).. Most moles present with painless vaginal bleeding during the second trimester of pregnancy

Hydatidiform Mole - Women's Health Issues - MSD Manual


Hydatidiform mole: MedlinePlus Medical Encyclopedi

IA hydatidiform mole is a non viable pregnancy. There is no fetus. Very rarely there are fetal pieces but no heart rate which means no viability. It forms from improper fertilization. So there is either 1 ovum and 2 sperm that fertilize or an empty ovum so no maternal DNA and 1 sperm Hydatidiform mole (HM) or molar pregnancy is the most common form of GTD. It is most often benign (non-cancerous) and stays in the uterus. There are two types. Most of these tumours occur after a full-term pregnancy, but they may arise after a spontaneous abortion or evacuation of hydatidiform mole. Vaginal bleeding is the presenting symptom in two-thirds of patients; about one third of patients present with metastatic disease. Serum beta human chorionic gonadotrophin (hCG) levels are mildly elevated and preterm labor.5,6,8 A potentially fatal complication of molar pregnancies is the risk of persistent gestational trophoblastic dis-ease (pGTD).2,6,10 The incidence of pGTD after surgical evacu-ation in complete hydatidiform mole with fetus is considerably higher as compared to partial hydatidiform mole with fetus (10

The hydatidiform mol

CASE REPORT: A Hydatidiform Mole Can Cause Severe

a rare complication of pregnancy known as a hydatidi-form mole (complete or partial). These hydatidiform moles belong to the gestational trophoblastic diseases of which represent the most common pathologies. These are the only pathologies of the group that can be recur-rent in the same patient. The recurrent moles are a rare disease, and management of hydatidiform mole John R. Lurain, MD G estational trophoblastic disease (GTD) is a spectrum of cellular proliferations arising from the placental villous trophoblast encompassing 4 main clinicopathologic forms: hydatidi- Medical complications. Hydatidiform moles are non-viable genetically abnormal conceptions with excess expression of paternal genes and abnormal proliferation of the placental trophoblast. Women diagnosed with hydatidiform mole should be registered with a regional centre for regular monitoring of human chorionic gonadotrophin to check for onset of malignancy Hydatidiform mole (H mole) is a rare complication of pregnancy, characterized by an atypical trophoblastic proliferation and swelling of the chorionic villi, with or without a live fetus. A clinical diagnosis of H mole is confirmed by significantly high serum beta-hCG levels and/or the presence of characteristic sonographic and histopathologic.

Hydatidiform Mole Nursing Diagnosis Interventions and Care

Hydatidiform mole/molar pregnancy Complications During

plete moles have a clinical or ultrasonographic diagnosis of hydatidiform mole. Uterine enlargement beyond the expected gestational age is observed in up to 50% of patients with complete moles (1). These patients may present with vaginal bleeding or expulsion of molar vesi-cles. Medical complications of molar pregnancy, includ hydatidiform mole: Definition A hydatidiform mole is a relatively rare condition in which tissue around a fertilized egg that normally would have developed into the placenta instead develops as an abnormal cluster of cells. (This is also called a molar pregnancy.) This grapelike mass forms inside of the uterus after fertilization instead of a. Hydatidiform moles are identified in approximately 1:1000 pregnancies while gestational choriocarcinoma complicates 1:20,000-40,000 pregnancies in the United States

What is a Molar Pregnancy?Choriocarcinoma_Gestational Trophoblastic Disease - Home

Diagnosis and management of hydatidiform mole and its

Hydatidiform mole is a gross malformation of the placenta, caused by a hydropic degeneration of all the chorionic villi with a more or less marked proliferation of trophoblasts.7 In this situation, the fetus is deprived of oxygen and nutrition nd will eventually die.1 The condition may develop into Hydatidiform Mole and Choriocarcinoma UK Information and Support Service. Hou JL, Wan XR, Xiang Y, et al; Changes of clinical features in hydatidiform mole: analysis of 113 cases. J Reprod Med. 2008 Aug53(8):629-33. The Sheffield Trophoblastic Disease Centr Pulmonary deportation of hydatidiform mole is an exceedingly rare entity. The underlying mechanisms and proper management strategies remain unclear based on sporadic case reports over the past six decades. This study aimed to investigate the clinical features and rational treatment of patients with benign molar pregnancies with pulmonary.

Complications Of Molar Pregnancy - ePainAssis

Complications following ectopic and molar pregnancy. According to the amount of villous involvement, a hydatidiform mole is defined as complete or partial. Most molar pregnancies are complete and are characterized by generalized hydropic villous changes. Partial moles are characterized by a mixture of large hydropic villi and normal. Partial hydatidiform moles coexisting with fetal tissue or an anomalous fetus generally result from dispermy and have a triploid karyotype in the majority of cases (Szulman and Surti, 1978a, b; Ohama et al., 1986). Fetuses with triploidy cannot survive after birth because of multiple malformations and severe intrauterine fetal growth retardation supposed to develop into the placenta. Hydatidiform mole (molar pregnancy) is the non-malignant form of gestational trophoblastic neoplasia.1,2 It is of clinical and epidemiological interest because of its significant complication in pregnancy. Hydatidiform moles are non-viable, genetically abnormal conceptions, showing excessive expression of.

Hydatidiform mole: Recognition and managemen

Hydatidiform Mole. A 27-year-old female presents to the emergency department at 11 weeks of gestation with 2 days of vaginal bleeding and pelvic pressure, as well as multiple daily episodes of nonbloody, nonbilious emesis over the past week. The patient states the bleeding is like heavy spotting with dark purplish-colored blood Twin pregnancy with a complete hydatidiform mole and co-existent fetus (CHMCF) is extremely rare. Its incidence was reported to be one per 22,000-100,000 pregnancies [1, 2].Although survival of the co-existent fetus in CHMCF cases is important, it is not easy to preserve this type of fetus Other gestational complications included pre-eclampsia and hyperthyroidism in this case. The non-affected placenta and fetus were structurally normal, but previable. The pathologic features in this case are diagnostic of complete hydatidiform mole. Complete moles are characterized by markedly hydropic villi which may grossly resemble a bunch. As with complete hydatidiform mole, the majority of patients with partial hydatidiform mole (75%) complain of vaginal bleeding; they generally present later than those with complete hydatidiform mole. Complete hydatidiform moles are typically associated with a considerably elevated β-hCG level

Diagnosis at a Glance: Partial Hydatidiform MolarPreimplantation genetic diagnosis molar pregnancy

Hydatidiform mole - SlideShar

We present a case of hydatidiform mole with non-metastatic pulmonary complications and stress that termination of the pregnancy will cure the patient. The frequent use of sonography in early pregnancy makes it possible to diagnose pathological pregnancies earlier than was possible before. The fact. Gestational trophoblastic disease includes a spectrum of interrelated tumors, including complete hydatidiform mole (CHM) and partial hydatidiform mole (PHM), invasive mole, choriocarcinoma, placental site trophoblastic tumor (PSTT), and epithelioid trophoblastic tumor (ETT). 1 -3 After CHM and PHM, gestational trophoblastic neoplasia (GTN.

Molar Pregnancy, Hydatidiform Mole - Causes, Symptoms

Treatment of hydatidiform mole with severe pregnancy-induced hypertension If moles with severe pregnancy-induced hypertension, blood pressure reaches 160/110mmHg, especially heart failure or eclampsia, should be treated symptomatically, control heart failure, sedation, lowering blood pressure, diuresis, and clearing the uterus after the. complications whatsoever. DISCUSSION Hydatidiform mole is abnormal pregnancy which should be evacuated as soon as possible, and follow-up is most important. 3 Invasive mole may totally penetrate the myometrium and be associated with uterine rupture and Figure 1: Uterus with perforating mole Figure 2: Histopathology of invasive mole

First trimester bleeding

Correct response: hydatidiform mole. Explanation: Reference: Ricci, S. S., Kyle, T., & Carman, S., Maternity and Pediatric Nursing, 4th ed., Philadelphia, Wolters Kluwer, 2021, Chapter 19: Nursing Management of Pregnancy at Risk: Pregnancy-Related Complications, Gestational Trophoblastic Disease, p. 667. Chapter 19: Nursing Management of Pregnancy at Risk: Pregnancy-Related Complications. It is characterized by the presence of a hydatidiform mole (or hydatid mole, mola hydatidosa). Molar pregnancies are categorized as partial moles or complete moles, with the word mole, being used to denote simply a clump of growing tissue, or a growth. Specialty: Oncology. MeSH Code: D006828. ICD 9 Code: 630 Hydatidiform mole with hyperthyroidism - perioperative challenges Dave Nandini 1, Fernandes Sarita 2, Ambi Uday 3, Iyer Hemalata 1 Associate Professor, 2 Lecturer, 3 Resident, 4 Professor & Head of Department Department of Pathology TN Medical College and BTL Nair Hospital, Mumbai - 400008. Key words : hydatidiform mole, hyperthyroidism. Hydatidiform mole is one of the most common complications of gestational trophoblastic diseases (GTD), which affects 0.6-1.1 per 1000 pregnancies [].Asia including China has a higher incidence of this disease [], and we have recently reported that the cases of hydatidiform mole were significantly increased in China in the last decade []..